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Trehalose Protects Epithelial and Endothelial Cells E-mail
Trehalose Protects Epithelial and Endothelial Cells

Comments by J. C. Spencer

“Trehalose protects cells” is a claim we have made for a number of years. But, we needed more research to support this claim. Here is a study that shows trehalose protects the endothelial cells and the corneal epithelial cells. Trehalose functionality in this paper deals with treating dry eye which further supports our statements for improving hydration of the cells.

Endothelial cells are a specialized type of epithelial cell which forms the inner layer of blood vessels. Epithelial cells help to protect or enclose organs; some produce mucus or other secretions. Certain types of epithelial cells have tiny hairs called cilia, which help remove foreign substances. The significance of these cells is that they play a key role in angiogenesis, the development of new blood vessels from pre-existing vessels. Angiogenesis is a multi-step process that is important for both physiological and pathological development. During angiogenesis, endothelial cells are activated and express matrix metalloproteinases (MMPs), which degrade the vascular basement membrane. In response to environmental cues, endothelial cells secrete MMPs and then invade through the basement membrane to form new capillary networks.

Read more...
Trehalose pH Fusion Tea is NOW Available E-mail
Introduction of Trehalose pH Fusion Tea™

Comments by J. C. Spencer

Recent discoveries have brought us to a better understanding of trehalose and especially how trehalose interacts with alkaline-earth metal ions. We have also learned that trehalose appears to remain functional even in an acid state. We recently posted on our website at www.endowmentmed.org an abstract of a paper published by the National Institutes of Health (NIH) on The U. S. National Library of Medicine website at PubMed.gov about trehalose research in Japan and its interaction with alkaline-earth metal ions.

This and other information is in The Trehalose Handbook Volume One that can be downloaded FREE at www.pHmarker.com More data will be available in The Trehalose Handbook Volume Two very soon. This new Trehalose Handbook will discuss the benefits of the many natural trace minerals in fulvic acid dry phytochemical base found in the Trehalose pH Fusion Tea™ . Students of glycomics will find this fascinating because it is the sugar’s role to help make it all happen.

Newly Discovered Sugar Switches Responsible for Dividing Cells E-mail
Newly Discovered Sugar Switches Responsible for Dividing Cells

by J. C. Spencer

Research shows the sugar O-Linked β-N-acetylglucosamine (O-GlcNAc) plays a role in cell division. N-Acetylglucosamine (N-acetyl-D-glucosamine, or GlcNAc) is a monosaccharide derivative of glucose and one of the building blocks for glycoproteins. It is an amide between glucosamine and acetic acid. Understanding these newly discovered sugar switches reveals that the cellular circuitry is much more complex than previously thought. GlcNAc is generally not elongated or modified to form the more complex sugar structures. O-GlcNAc is attached and removed multiple times in the life of a polypeptide, often cycling rapidly and at different rates at different sites on a polypeptide.

The chemical changes act more like "dimmer" switches, than simple on/off switches. The communication between O-GlcNAc and phosphorylation is a paradigm-shift in terms of signaling. So says Gerald Hart, PhD director of biological chemistry at Johns Hopkins School of Medicine. He added, "I think of phosphorylation as a micro-switch that regulates the circuitry of cell division, and O-GlcNAcylation as the safety switch that regulates the microswitches,"

Now, here is the Report from Science News

Read more...
Interaction Between Trehalose and Alkaline-earth Metal Ions E-mail
Interaction Between Trehalose and Alkaline-earth Metal Ions

by J. C. Spencer

During the last few months I have been experimenting with the sugar trehalose as the base for a complex composition formulated with specific trace minerals and a delivery system that penetrates the human cell. We have formulated a proprietary composition that may have profound health benefits as a functional food. Does it work and is it actually beneficial? More research is needed and will be ongoing. More information about this work will be in Volume Two of The Trehalose Handbook. Meanwhile, you may download a free copy of the 93 page e-handbook Volume One online from the website www.pHmarker.com.

Below is the abstract of a science paper entitled Interaction between trehalose and alkaline-earth metal ions. Students of glycomics will appreciate this finding.

Read more...
Our Gift To You - Free E-book On Trehalose E-mail

As part of our Educational Program and because of your interest in the education of good sugars, you can receive my complimentary GIFT [valued at $30]. I have written (with the help of some experts) The Trehalose Handbook e-book that is yours FREE.

To receive your GIFT just click on www.pHMarker.com

Chapter Six in The Trehalose Handbook is called Trehalose pH Fusion. This NEW information can be of great value to you and your family.

By the way, your friends can also receive this FREE GIFT. Just forward to them the Link at www.pHMarker.com

Trehalose Plays Role in cDNA Research E-mail
Trehalose Plays Role in cDNA Research

by J. C. Spencer

One word that is continually attributed to the sugar trehalose is STABLE. It helps stabilize cells, enzymes, proteins, DNA and the research goes on. Trehalose is used in synthesizing full length cDNA because it helps enzymes maintain their activity at higher temperatures where they normally become inactive.

Here is the research carried out in Japan.

Read more...
Trehalose Glycolipids have Amazing Function E-mail
Trehalose Glycolipids have Amazing Function

by J. C. Spencer

Trehalose is one of the sugar building blocks that creates great cellular communication. Here is evidence that trehalose is the sugar used to build unique glycolipids. Trehalose is the building block in a number of cell wall glycolipids. Glycoproteins are more on the cell surface while glycolipids do most of their work in the cell wall and within the cell itself.

Sugars are the OPERATING SYSTEM (OS) of the body, processing DNA data, thought, and all cellular communication. Glycomics, the science of sugars, may be thousands of times more complex than the genome project. The eight Royal Sugars used to construct glycoprotein receptor sites that coat every healthy human cell were described by Robert K. Murray, M.D., PhD, in Harper’s Biochemistry first in 1996 and then in subsequent editions [and discussed in layman’s language in my e-textbook Expand Your Mind - Improve Your Brain, foreword by Dr. Murray ]. Our dear friend Dr. Rob, as we affectionately call him, is from Scotland and he will be glad to know some of the work you are about to read came out of the Lipid Analysis Unit of the Scottish Crop Research Institute in Dundee.

Read more...
New Uses for Trehalose - Add to EVERY Recipe - Here's Why E-mail
New Uses for Trehalose - Add to EVERY Recipe - Here’s Why

by J. C. Spencer

We have learned of new uses for the healthful sugar trehalose that you can share with your family and friends this Christmas Season. The multi-reasons trehalose can be added to almost every dish include 1) trehalose enhances flavor; 2) trehalose increases health benefits; 3) trehalose keeps water pockets from forming when refrigerated or frozen; 4) trehalose helps preserve food and extend life and freshness; 5) trehalose is a simple way to reduce you and your family's use of bad sugars. And, 6) make this a Season you are not worried about too much sugar - because trehalose is the GOOD sugar.

Some of the new uses for trehalose include meats in the early stages of preparation, like beef, pork, deer and fowl sausage and hamburger. Sprinkle and mix trehalose throughout the sausage or hamburger meat. Because trehalose is only 45% as sweet as table sugar, you are not as concerned with making the dishes too sweet. With cookies, brownies, pies, and cakes, if you replace table sugar with trehalose, they will not be as sweet but that may be a good thing. An interesting side benefit seems to be that the more trehalose one eats, the more the crave for sugar is removed. Diabetics are encouraged to continue to monitor their sugar load; however, diabetics are indicating that their sugar balance is more normal while using trehalose. More information is available at www.DiabeticHope.com

You are welcome to view recipes and share your recipes with us on Sugar Science Forum at www.endowmentmed.org or simply e-mail them to us at jcs@endowmentmed.org. Give trehalose to your friends this Christmas. View the creative ideas on our Home Page.

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