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NEWS FLASH - Monitoring Sugars On Cells Will Forever Change Healthcare!

NEWS FLASH February 28, 2013

by JC Spencer

Today, an announcement was made in an open access published paper from the Hokkaido University in Japan entitled: Recent Advances in Cellular Glycomic Analyses.

The ability to analyze the cellular glycome extensively and completely will open new avenues in systems biology glycomics. The future of all medicine and healthcare will more sharply focus in on glycoscience.

How sugars form on the surface of healthy cells is called glycosylation (gli-ko?s?-la´shun). The quality and quantity of these sugar forms give quality and longevity of life to the cell. To gain ability to count and calibrate these glycoproteins is the Holy Grail of medical diagnostic technology.

Researchers at the Laboratory of Medical and Functional Glycomics, Graduate School of Advanced Life Science and Frontier Research Center for Post-Genome Science and Technologies present the advancements toward the Gold Standard in Medical Diagnostics. Focusing on these recent advancements, the paper shows that Glycomics is proving to be many times more complex than the genome project.

Glycosylation profiling based on carbohydrate-recognizing molecules provides valuable information about sugar epitopes (A localized region on the surface of an antigen that is capable of eliciting an immune response and of combining with a specific antibody to counter that response.). The researchers found that it is often difficult to differentiate between different glycoconjugate species with current methods.

Comprehensive identification of pluripotency biomarkers and disease-related biomarkers will continue to be accelerated.

An understanding of the entire cellular glycome is expected to expedite development of more specific biomarkers and equipment that can count, analyze, and differentiate glycoproteins on the surface of various cells and predict the propensity those cells.

All of the major classes of glycans are under investigation. Development of new techniques for multiplexing is underway to improve throughput of glycomic studies for analysis. Improved informatics to link and interpret data obtained by different methods is moving forward worldwide.

I first reported on this diagnostic technology in July 2008 in an article entitled: Measuring Glycoproteins - Future of Diagnostics. Two followup lessons were: Glycomics IS the Answer to Cancer for prevention, detection, and diagnosis; and, Glycomics Cancer Diagnostics - How it will work! Report on Europe, China, Japan, Russia, and US.

Recent Advances in Cellular Glycomics Analyses may be downloaded here at http://www.mdpi.com/2218-273X/3/1/198/pdf

Transforming Glycoscience - A Roadmap for the Future, by National Research Council of the National Academies. Introduction pg 15 - Important Facts About Glycans, Health 1. “Elimination of any single major class of glycans from an organism results in death.”