Nat Med. 2004 Feb;10(2):123-4.

Tanaka M, Machida Y, Niu S, Ikeda T, Jana NR, Doi H, Kurosawa M, Nekooki M,
Nukina N. Laboratory for Structural Neuropathology, RIKEN Brain Science
Institute, 2-1 Hirosawa, Wako City, Saitama 351-0198, Japan.

Abstract:

Inhibition of polyglutamine-induced protein aggregation could provide treatment
options for polyglutamine diseases such as Huntington disease. Here we showed
through in vitro screening studies that various disaccharides can inhibit
polyglutamine-mediated protein aggregation. We also found that various
disaccharides reduced polyglutamine aggregates and increased survival in a cellular
model of Huntington disease. Oral administration of trehalose, the most effective of
these disaccharides, decreased polyglutamine aggregates in cerebrum and liver,
improved motor dysfunction and extended lifespan in a transgenic mouse model of
Huntington disease. We suggest that these beneficial effects are the result of
trehalose binding to expanded polyglutamines and stabilizing the partially unfolded
polyglutamine-containing protein. Lack of toxicity and high solubility, coupled with
efficacy upon oral administration, make trehalose promising as a therapeutic drug
or lead compound for the treatment of polyglutamine diseases. The saccharidepolyglutamine
interaction identified here thus provides a new therapeutic strategy for
polyglutamine diseases.

Harmful sugars

An outstanding authority on the dangers of the sugar succrose is Nancy
Appleton, PhD, and author of a number of books including Lick The
Sugar Habit. Dr. Appleton is one of the leading crusaders about how
sugar can damage your health.

In addition to throwing off the body's homeostasis, excess sugar may result in a
number of other significant consequences.

Dr. Appleton, in a Gatlin-gun approach, lists some of sugar's metabolic
consequences from a large number of medical journals and other scientific
publications which are carefully referenced at the end of the book. All sugars are
not bad, some are good; and indeed, there are royal sugars as I will discuss.

In April 1998, I wrote a paper Good Sugars vs. Bad Sugars. Quote from paper:
“Bad sugars may contribute to heart disease, cancer, stroke, bronchitis,
osteoarthritis, rheumatoid arthritis, ADD, ADHD, chronic fatigue, and fibromyalgia.

The following statements are supported by over 200 references from publications
and published papers. (See Glossary of Expand Your Mind - Improve Your
Brain) for references and supporting evidence.