Easy Find It Page
Easy Find It
Use Our Mobile Site
Use Our Mobile Site
Share This Website
The Sugar Trehalose
Free NEWS Letter
Affiliate Program
Untitled Document

Already an Affiliate? Click on the link below to access your account-

Affiliate Login

Endowment Book Store
The Trehalose Store
Endowment Store Front
Support The Endowment
Enter Amount:
We Accept
VisaMaster CardAmerican ExpressDiscoverssl lock
Download Store

Download Store

Download 7 Free Newsletters Plus Other Educational Materials

Main Menu
Home
- - - - - - -
Inside the Human Cell
The Sugar Trehalose
- - - - - - -
Sugar Science Forum
Glycomics Training
Interactive Glycomics Brochure
NEWS
7 FREE NEWSletters
HOT Links of Interest
- - - - - - -
Contact Us
Disclaimer
Sitemap
Educational e-textbook
Chapter One

Chapter One

FREE Sneek Peek
Chapter One


Evaluation Forms

Huntington’s General
Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

Parkinson's General
Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

Alzheimer / Dementia
General Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

Diabetic Health Evaluation
FORM for Trehalose
Nutritional Pilot Survey

General Public Health
Evaluation FORM for
Trehalose Nutritional
Pilot Survey (For General
Public without Huntington’s,
Alzheimer’s, or Parkinson’s.)

Who's Online
We have 43 guests online
Reprogramming Adult Stem Cells in Parkinson’s Study

Mature Cells Reprogrammed to Act Like Stem Cells in Parkinson's Study

(April 11, 2008 - Insidermedicine) An animal model of Parkinson's disease has been successfully treated via transplantation of mature cells that have been reprogrammed to act like embryonic stem cells, according to research published in the Proceedings of the National Academy of Sciences.
Here are some recommendations for initiating treatment for Parkinson's disease from the American Academy of Neurology:

•    Consider initial symptomatic treatment with selegiline in order to confer mild, symptomatic benefit prior to the institution of dopaminergic therapy.

•    Use either levodopa or a dopamine agonist in patients who require the initiation of dopaminergic treatment. The choice depends on the relative impact of improving motor disability (better with levodopa) compared with the lessening of motor complications (better with dopamine agonists).

•    Consider using either an immediate-release or sustained-release preparation for patients in whom levodopa treatment is being instituted.

Researchers out of the Whitehead Institute for Biomedical Research in Cambridge induced pluripotency in mouse fibroblasts by using retroviruses to insert four genes: Oct4, Sox2, Klf4, and c-Myc. They then implanted these induced pluripotent stem cells into the brains of fetal mice as well as into the midbrains of adult rat models of Parkinson's disease.

The implanted cells migrated into the surrounding tissue and gave rise to mature, functioning brain cells. The cells transplanted into the midbrain of the rat models of Parkinson's disease gave rise to mature dopamine neurons and improved the animals' symptoms.

Today's research demonstrates that mature cells can be reprogrammed to act like stem cells, which upon implantation give rise to functioning dopamine neurons in the midbrain. In humans, such a strategy could provide a transplantation-based treatment for Parkinson's disease that overcomes issues of immunorejection, since the transplanted cells differentiate into mature cells containing the host's DNA.

For Insidermedicine in Depth, I'm Dr. Susan Sharma.

Last Updated ( Aug 01, 2008 at 02:34 PM )